(650) 342-7432

100 S. Ellsworth Ave.
Suite 507
San Mateo, CA 94401
(650) 342-7432

Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors affecting the gastrointestinal tract; however, they account for 0.1 to 3% of all gastrointestinal malignancies. GISTs originate from peacemaker cells known as interstitial cells of Cajal (ICC) that are found in the gastrointestinal tract, whose function is to control gut motility. GISTs express the transmembrane receptor c-kit (CD117), which has a tyrosine kinase activity and is codified by c-kit protooncogene. In general, the ligand for c-kit receptor is the stem cell factor (scf). Gastrointestinal stromal tumors can occur anywhere along the length of the digestive tract, however, the most frequent sites for these types of tumors to arise are: the stomach (70%), the small intestine (20%) and the esophagus, the colon and the rectum (10%). Sometimes they also occur in the omentum, the mesentery or the peritoneal cavity. The people with a higher incidence to suffer from GISTs are those who are between 50 and 70 years old, its prevalence being equal both in men and women.



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100 S. Ellsworth Ave
Suite 507
San Mateo CA, 94401